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KMID : 0378120020290010125
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Chungnam Medical Journal
2002 Volume.29 No. 1 p.125 ~ p.138
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A Retrospective Study on Treatment Results of Laryngeal Cancer
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Kim Seong-Eun
Shin Hyun-Young
Kwak Seung-Keon
Park Sang-Eun
Park Su-Jin
Yun Hwan-Jung
Jo Deog-Yeon
Kim Sang-Yong
Kim Byeong-Kook
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Abstract
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Laryngeal cancer-the most common malignant tumor within head and neck-is known for its better prognosis when we compare with the other malignancies. In this paper, We analyzed retrospectively results of operation, radiotherapy and chemotherapy of laryngeal cancer to find out the response rate, survival rate and prognostic factor.
75 consequent laryngeal cancer patients who have been treated at CNUH during the period of 1995 to 2000 were studied.
The patients are consisted of 72 males and 3 females. The primary site were; glottis in 45 patients, supraglottis in 29 patients, and subglottis in 1 patient. 96% had squamous cell carcinoma and 98% of evaluable patients had history of smoking. Glottic cancer was detected earlier and showed much better prognosis than supraglottic cancer (p <0.001). 45 patients received radiotherapy while 17 patients underwent surgery and post -operative radiotherapy. Complete remission rate after radiotherapy was 85.7% in glottic cancer patient.
Three year overall survival rate was 85.4 % in total. Significant prognostic factor for 3-year overall survival and 3-year disease free survival on univariate analysis were stage, T stage, and primary site. 3-year overall survival rate was higher in patients with negative lymph node involvement. Progression or recurrence usually occurred within 12 months in responsive group. Chemotherapy was the primary treatment modality in 9 patients and 6 patients recieved additive radiotherapy. Among 9 patients, 2 patients obtained complete remission and 1 patient achieved partial response after subsequent radiotherapy.
Advanced cancer patients after surgery with radiotherapy achieved high survival rate, but lost larynx function. We need to develop better strategies to increase both voice preservation and survival rate in patients with advanced laryngeal cancer.
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KEYWORD
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Laryngeal cancer, Treatment result
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